Here are the official inactive players lists for both teams for today’s game:

Colts:  QB Peyton Manning, QB Kerry Collins, T Anthony Castonzo, DB Kevin Thomas, RB Joseph Addai, DE Jerry Hughes, DT Drake Nevis

Bengals: LB Rey Maualuga, WR Ryan Whalen; LB Dontay Moch; S Robert Sands; TE Colin Cochart; G Clint Boling; CB Kelly Jennings

Obviously, the Colts are a different team without Manning, and Addai’s absence will hurt an already bad Colts rushing attack.  As for the Bengals, Rey Maualuga’s absence might hurt their #1 ranked defense.  Dan Skuta fills in there.